Our Research Approach - Bridging discovery and biotechnology-driven framework
Specifically, the research aims to (1) evaluate how bioprocessing parameters impact cell growth, metabolic profile, and productivity and (2) harness the knowledge towards optimizing bioprocessing parameters to achieve robust cell culture growth, cell line stability, and maximize product yields.
Link to Publications
Ongoing Projects:
- Nucleases represent the "next frontier" in precision medicine and have enabled transformative treatments for genetic diseases and cancer immunotherapy. Cas9 (CRISPR-associated protein 9), within the CRISPR-Cas9 gene-editing tools, represents the primary model for this technology. Despite CRISPR/Cas9's potential, the clinical translation of these tools is hindered by high production costs and the technical difficulty of manufacturing high-purity safe and effective products. Our lab focuses on scalable production through strain engineering and bioprocess optimization to increase product yields. Our long-term goal is rational design and production of novel nuclease variants. These engineering efforts provide the foundational components for broader medical breakthroughs.
- In parallel, our lab also remains committed to production and analysis of other value-added biomolecules as collaborative opportunities arise.
- A second aim of the lab focuses on developing cell-based and biomolecular interaction assays to evaluate biomolecules’ biological activity and potency.
Collaborate With Us
We actively seek collaborations with academic institutions, industry partners, and other research groups who share our passion for advancing gene editing and biopharmaceutical technologies. We believe that working together can accelerate discoveries and translate them into real-world solutions faster.
If your work aligns with our expertise in nuclease engineering, CHO cell line development, bioreactor scale-up, product purification, and biomolecular interaction studies, we invite you to connect with us. Let's explore how our combined efforts can lead to groundbreaking innovations.
Please reach out to us at [email protected] to discuss potential collaborative opportunities.